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Tests and Information required for Pesticides Toxicological
Evaluation
a) Quality and quantitative composition of the total product
Total concentration of active, inert and other ingredients, plus identity
of all the components of the formula. Identity, concentration and toxicity,
when applicable, of the impurities or by-products present in the technical
product.
b) Physiochemical properties of the product
Degree of purity, physical state, appearance, color, odor, pH, volatility,
steam pressure, corrosiveness, etc.
c) Toxicological Tests ( Annex I of Administrative Rule 3, 16/01/92)
Acute Oral Toxicity (DL50 Oral)
Acute Dermal Toxicity (DL50 Dermal)
Acute Inhaled Toxicity (CL50)
Acute ocular irritation
Acute skin irritation
Skin sensitivity
Dermal Toxicity 21/28 days
Short term toxicity, two species of animals, one of which is none-rodent
Long term toxicity
Carcinogenic Potential
Effects on reproduction and offspring, in three successive generations
Teratogenic Effects
Mutagenic Effects
Delayed Neurotoxicity
Metabolism and excretory ducts as well as the average biological life
of laboratory animals. Toxicity of the metabolites if different in plants
and animals.
d) Tests for Research on Residues
(Annexes IV and V of Administrative Rule 16/01/92 - Ministry of Health,
with alterations published in Resolution RDC 44, of 10/05/02.
Field tests and analyses of the active ingredients remaining in food.
The aim of these tests is to enable an estimate to be made of residue
levels in food, arising from products of animal or vegetable origin, in
cases where the raw materials and derivatives are intended for human consumption
in their natural state or following their transformation by technological
process, for which it is necessary to fix a top recommended limit regarding
pesticides and their derivatives.
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